Studies

Research Studies

IMAGINE brings together gastroenterologists, neuroscientists and psychiatrists, currently working in isolated silos, into a network focused on:

  • defining the bidirectional communication between the gastrointestinal tract and central nervous system, and
  • how alterations of the gut microbiome may influence anxiety and depression associated with gastrointestinal disorders.

The overall aim of IMAGINE is to identify the key mechanisms in the diet-microbiome-host relationship and test novel therapies for treatment of IBS, IBD and associated psychiatric disorders.

1. Microbiome Changes in Inflammatory Bowel Disease & Irritable Bowel Syndrome
This project will study how three important variables (genes, diet and mental health) impact the gut microbiome in persons with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and in turn how together they impact the disease course.

Recruitment sites for this study:

McMaster University

Address: 1280 Main Street West Hamilton, Ontario L8S 4K1
Phone: 905-521-2100 x 73601
Lead Investigator: Paul Moayyedi
Contact: Melanie Wolfe

University of Manitoba

Address: 66 Chancellors Cir, Winnipeg, Manitoba R3T 2N2
Phone: 204-787-4740
Lead: Dr. Charles Bernstein
Contact: Geetika Grover

Queen's University

Address: 99 University Ave, Kingston, Ontario K7L 3N6
Phone: TBD
Lead: Dr. Stephen Vanner
Contact: Celine Morissette

University of Alberta

Address: 116 St & 85 Ave, Edmonton, Alberta T6G 2R3
Phone: TBD
Lead: Dr. Richard Fedorak
Contact: Lindsy Ambrosio

University of Calgary

Address: 2500 University Dr NW, Calgary, Alberta T2N 1N4
Phone: TBD
Lead: Dr. Gil Kaplan
Contact: Nusrat Shommu

IWK Health Centre

Address: 6299 South St, Halifax, Nova Scotia B3H 4R2
Phone: TBD
Lead: Dr. Anthony Otley
Contact: Amy Postmaa

Sick Kids Toronto

Address: 555 University Ave, Toronto, Ontario M5G 1X8
Phone: TBD
Lead: Dr. Anne Griffiths
Contact: TBD

McGill University

Address: 845 Rue Sherbrooke O, Montréal, Quebec H3A 0G4X8
Phone: TBD
Lead: Dr. Alain Bitton
Contact: TBD

University of Ottawa

Address: 75 Laurier Ave E, Ottawa, Ontario K1N 6N5
Phone: TBD
Lead: Dr. Alaa Rostom
Contact: TBD

University Health Network (UHN)

Address: 600 University Ave, Toronto, Ontario M5G 1X5
Phone: TBD
Lead: Drs. Ken Croitoru, Louis Liu & Geoff Nguyen
Contact: Rhea O’Neill

University of Saskatchewan

Address: Saskatoon, Saskatchewan S7N 5C5
Phone: TBD
Lead: Dr. Sharyle Fowler
Contact: TBD

Nova Scotia Health Authority

Address: 5790 University Ave, Halifax, NS B3H 1V7, Canada
Phone: TBD
Lead: Dr. Jennifer Jones
Contact: Slava Khovratovich

 

2. Fecal Microbial Therapy in Ulcerative Colitis
This project will use antibiotic pre-treatments to see if the success of fecal microbial therapy (FMT) is improved in patients with ulcerative colitis (UC).

Recruitment sites for this study:

McMaster University

Address: 1200 Main St. W. Hamilton, ON. L8S 4K1
Phone: 905-521-2100 x 73601
Lead: Dr. Paul Moayyedi
Contact: Melanie Wolfe

3. Fecal Microbial Therapy in Crohn’s Disease
This project will determine whether fecal microbial therapy (FMT) can improve symptoms in patients with Crohn’s disease (CD).

Recruitment sites for this study:

McMaster University

Address: 1200 Main St. W. Hamilton, ON. L8S 4K1
Phone: 905-521-2100 x 73601
Lead: Dr. Paul Moayyedi
Contact: Melanie Wolfe

University of Alberta

Address: 116 St & 85 Ave, Edmonton, Alberta T6G 2R3
Phone: TBD
Lead: Dr. Dina Kao
Contact: Brandi Roach

4. PET Imaging Study
This study will be brain scanning patients with IBD who are also clinically depressed to better understand how the two relate to each other.

Recruitment sites for this study:

McMaster University

Address: 1280 Main Street West Hamilton, Ontario L8S 4K1
Phone: 905-521-2100 x 73601
Lead Investigator: Paul Moayyedi
Contact: Melanie Wolfe

Centre for Addiction and Mental Health (CAMH)

Address: 250 College Street, Room B26, Toronto, Ontario, M5T 1R8
Phone: 416-535-8501 x 33677
Lead Investigator: Jeff Meyer
Contact: Cynthia Xu

5. Cognitive Behavioural Therapy for Mental Health
This project will determine whether online cognitive behavioral therapy (CBT) is effective in treating depression or anxiety in IBD patients.

Recruitment sites for this study:

University of Winnipeg

Address: 66 Chancellors Cir, Winnipeg, Manitoba R3T 2N2
Phone: TBD
Lead: Dr. Charles Bernstein
Contact: TBD

6. Low FODMAPS Diet in Irritable Bowel Syndrome
This project will determine whether a low FODMAP diet can improve symptoms in IBS patients

Recruitment sites for this study:

Queen's University

Address: 99 University Ave, Kingston, Ontario K7L 3N6
Phone: TBD
Lead: Dr. Stephen Vanner
Contact: TBD

6. Patient Preferences in Inflammatory Bowel Disease Treatments
This study will help us understand what is important to people with inflammatory bowel disease (IBD) when choosing between treatments.

Recruitment sites for this study:

University of Calgary

Address: 2500 University Dr NW, Calgary, Alberta T2N 1N4
Phone: TBD
Lead: Drs. Deborah Marshall & Gil Kaplan
Contact: Brittany Shewchuk